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CS-W001157 4
Total: USD 88.00

11β-HSD1-IN-7

  • CAS No. 728-86-9

  • Cat. No. CS-0159838
  • Molecule weight250.22
  • Purity≥98%
  • MDL No.MFCD00000400

*For research and further manufacturing use only, not for direct human use.

11β-HSD1-IN-7|CS-0159838

Structure of 728-86-9

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General Information

  • CAS No. 728-86-9
  • Cat. No. CS-0159838
  • Purity ≥98%
  • MDL No. MFCD00000400
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₉F₃O
  • Molecular Weight 250.22
  • Synonym(s) None
  • SMILES O=C(C1=CC=CC=C1)C2=CC=C(C(F)(F)F)C=C2

Description

11β-HSD1-IN-7 is a potent, selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1, designed for research into metabolic and inflammatory pathways. This small molecule modulates glucocorticoid activation within tissues, offering utility in studying insulin resistance, adiposity, and neuroinflammation. Bench-stable and suitable for cellular assays under standard conditions.

Application

11β-HSD1-IN-7 serves as a well-characterized, selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), enabling targeted modulation of intracellular glucocorticoid activation. This compound functions as a valuable research tool for studying metabolic syndrome, insulin resistance, and neuroinflammation in preclinical models. Its defined steroidal scaffold offers high binding affinity and favorable stability in biological assays, facilitating consistent results across cellular and enzymatic studies.

Synthesis

  • Route1

    References

    • Pandey, Sanjay K.; Bisai, Alakesh; Singh, Vinod K. Synthetic Communications, 2007 , vol. 37, # 23 p. 4099 - 4103
  • Route2
    • In-stock
      4-Trifluoromethylphenylboronic acid|CS-W008762
      128796-39-4
    • null|null
      98-88-4
    • ~94%
    • In-stock
      11β-HSD1-IN-7|CS-0159838
      728-86-9

    References

    • Xin, Bingwei; Zhang, Yuhong; Cheng, Kai Journal of Organic Chemistry, 2006 , vol. 71, # 15 p. 5725 - 5731
  • Route3

    References

    • Yamamoto; Kakino; Narahashi; Shimizu Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 6 p. 1333 - 1345

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.9364
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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