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Structure of 72928-54-2
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4-(trans-4-Ethylcyclohexyl)benzonitrile features a rigid, sterically defined cyclohexyl scaffold linked via a trans-configured alkyl chain to an aromatic nitrile group. This structural motif imparts high thermal stability and favorable solubility in organic media, enabling its use as a building block in functional materials and pharmaceutical intermediates.
4-(trans-4-Ethylcyclohexyl)benzonitrile serves as a versatile building block in medicinal and process chemistry, enabling the construction of rigid, lipophilic scaffolds through standard Suzuki and Buchwald-Hartwig coupling reactions. The trans-ethylcyclohexyl group provides conformational stability and enhanced metabolic resistance, while the nitrile functionality offers direct access to amides and amines via hydrolysis or reduction. Bench-stable and readily purified by column chromatography, it functions effectively in multi-step synthesis workflows requiring robust functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: