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CS-W001157 4
Total: USD 88.00

3-(Piperidin-1-ylmethyl)phenol

  • CAS No. 73279-04-6

  • Cat. No. CS-W010722
  • Purity≥97%
  • MDL No.MFCD00800250

*For research and further manufacturing use only, not for direct human use.

3-(Piperidin-1-ylmethyl)phenol|CS-W010722

Structure of 73279-04-6

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General Information

  • CAS No. 73279-04-6
  • Cat. No. CS-W010722
  • Purity ≥97%
  • MDL No. MFCD00800250
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO
  • Molecular Weight 191.27
  • Synonym(s) None
  • SMILES OC1=CC=CC(CN2CCCCC2)=C1

Description

3-(Piperidin-1-ylmethyl)phenol features a phenolic hydroxyl group flanked by a piperidinomethyl substituent, delivering enhanced solubility and nucleophilicity. This scaffold integrates readily into bioactive molecules, serving as a key intermediate in medicinal chemistry for targeted drug discovery.

Application

3-(Piperidin-1-ylmethyl)phenol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard functional group transformations. Its phenolic hydroxyl group facilitates direct derivatization, while the piperidine moiety provides a basic nitrogen for salt formation and enhanced solubility. The benzylic linkage offers stability under routine reaction conditions and supports compatibility with common coupling and reduction protocols, making it suitable for iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      110-89-4
    • 3-Hydroxybenzaldehyde Roxatidine Impurity|CS-0229483
      100-83-4
    • ~97%
    • In-stock
      3-(Piperidin-1-ylmethyl)phenol|CS-W010722
      73279-04-6

    References

    • Buschauer; Postius; Szelenyi; Schunack Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 7 p. 1025 - 1029
  • Route2
    • null|null
      107417-55-0
    • ~90%
    • In-stock
      3-(Piperidin-1-ylmethyl)phenol|CS-W010722
      73279-04-6

    References

    • Mustazza, Carlo; Borioni, Anna; Giudice, Maria Rosaria Del; Gatta, Franco; Ferretti, Rosella; Meneguz, Annarita; Volpe, Maria Teresa; Lorenzini, Paola European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 91 - 109

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   2.3781
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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