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CS-W001157 4
Total: USD 88.00

2,4,6-Trichlorophenylboronic acid

  • CAS No. 73852-18-3

  • Cat. No. CS-W014215
  • Purity≥96%
  • MDL No.MFCD01074621
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trichlorophenylboronic acid|CS-W014215

Structure of 73852-18-3

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Description

2,4,6-Trichlorophenylboronic acid features a boronic acid group flanked by three chlorine atoms at the 2, 4, and 6 positions of the phenyl ring. This electron-deficient arylboronic acid exhibits enhanced stability and reactivity in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. The trichloro substitution improves solubility in organic solvents and facilitates handling in synthetic workflows.

Application

2,4,6-Trichlorophenylboronic acid serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its electron-deficient aryl boronic acid functionality enables efficient coupling with diverse halides and pseudohalides under mild conditions. The three ortho-chlorine substituents enhance reactivity while maintaining compatibility with common protecting groups and functional group tolerances. This compound facilitates rapid access to substituted biaryls and complex heterocyclic scaffolds in medicinal chemistry and materials synthesis.

General Information

  • CAS No. 73852-18-3
  • Cat. No. CS-W014215
  • Purity ≥96%
  • MDL No. MFCD01074621
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BCl₃O₂
  • Molecular Weight None
  • Synonym(s) 2,4,6-Trichlorobenzeneboronic Acid (contains varying amounts of Anhydride)
  • SMILES OB(O)C1=C(Cl)C=C(Cl)C=C1Cl

Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.3266
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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