2’,3’,5’-Tri-O-acetyl adenosine

Name: 2’,3’,5’-Tri-O-acetyl adenosine
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CAS No. 7387-57-7
Cat. No. CS-W009732
Purity≥97%
MDL No.MFCD00057001

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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2’,3’,5’-Tri-O-acetyl adenosine|CS-W009732

Structure of 7387-57-7

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Description

2’,3’,5’-Tri-O-acetyl adenosine features fully acetylated hydroxyl groups at the ribose 2’, 3’, and 5’ positions, enabling selective protection during oligonucleotide synthesis. This derivative facilitates efficient coupling reactions under standard conditions while maintaining stability in organic solvents.

Application

2’,3’,5’-Tri-O-acetyl adenosine serves as a key protected nucleoside building block for the synthesis of oligonucleotides and modified RNA analogs. The acetyl groups provide enhanced stability during storage and facilitate selective deprotection in synthetic sequences. Its well-established reactivity enables efficient coupling in solid-phase and solution-phase phosphorylation protocols, making it a reliable intermediate in the construction of biologically relevant nucleic acid scaffolds.

General Information

CAS No. 7387-57-7
Cat. No. CS-W009732
Purity ≥97%
MDL No. MFCD00057001
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₉N₅O₇
Molecular Weight 393.35
Synonym(s) Adenosine, 2',3',5'-triacetate
SMILES NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O3

Computational Chemistry Data

TPSA 157.75
LogP -0.2676
H_Acceptors 12
H_Donors 1
Rotatable_Bonds 5

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Life Science Nucleosides & Nucleotides Deoxyribonucleotides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleotide Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleotides

Key Words

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2’,3’,5’-Tri-O-acetyl adenosine

CAS No. 7387-57-7

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