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CS-W001157 4
Total: USD 88.00

1,3,3-Trimethylpiperazine

  • CAS No. 741288-57-3

  • Cat. No. CS-0225245
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3,3-Trimethylpiperazine|CS-0225245

Structure of 741288-57-3

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General Information

  • CAS No. 741288-57-3
  • Cat. No. CS-0225245
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂
  • Molecular Weight 128.22
  • Synonym(s) Piperazine, 1,3,3-trimethyl- (9CI)
  • SMILES CC1(C)CN(C)CCN1

Description

1,3,3-Trimethylpiperazine is a sterically hindered, bench-stable piperazine derivative featuring three methyl groups that enhance solubility and reduce nucleophilicity. This configuration imparts high stability under standard conditions while maintaining reactivity in amine coupling and catalyst ligand applications.

Application

1,3,3-Trimethylpiperazine serves as a versatile nitrogen-containing scaffold in medicinal chemistry, offering enhanced metabolic stability and improved solubility profiles. Its tertiary amine functionality enables efficient salt formation and facilitates interactions with biological targets. The molecule demonstrates excellent bench stability and compatibility with standard coupling reactions, making it a practical building block for fragment-based drug discovery and the synthesis of complex heterocyclic systems.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.3
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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