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Structure of 74173-77-6
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2,4-Dichloro-6-nitroquinazoline features a highly electron-deficient quinazoline core with dual chloro substituents at positions 2 and 4, enhancing reactivity in nucleophilic substitution. The para-nitro group at position 6 further stabilizes the system through resonance, enabling efficient coupling in C–N bond formation. This scaffold serves as a robust building block for kinase inhibitor development and advanced heterocyclic synthesis under standard bench conditions.
2,4-Dichloro-6-nitroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. Its dichloro substitution pattern facilitates selective nucleophilic aromatic substitution, while the nitro group provides a handle for downstream reduction and functionalization. The compound exhibits bench stability and compatibility with standard reaction conditions, making it well-suited for use in parallel synthesis campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: