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Structure of 74478-93-6
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Ethyl 2-bromo-1H-imidazole-5-carboxylate features a brominated imidazole core with a pendant ethyl ester, enabling direct functionalization in cross-coupling and heterocycle elaboration. The electron-deficient ring facilitates nucleophilic substitution, while the ester group supports further derivatization. This bench-stable reagent integrates efficiently into synthetic sequences requiring regioselective halogen handling.
Ethyl 2-bromo-1H-imidazole-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions at the C2 position. The bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings, facilitating the construction of biologically relevant imidazole scaffolds. Its bench-stable nature and compatibility with diverse functional groups make it ideal for iterative synthetic sequences in medicinal chemistry and process development workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: