6-Chloro-5-nitro-3-pyridinecarboxylic acid

Name: 6-Chloro-5-nitro-3-pyridinecarboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 7477-10-3
Cat. No. CS-W008886
Purity≥95%
MDL No.MFCD09027297

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-5-nitro-3-pyridinecarboxylic acid|CS-W008886

Structure of 7477-10-3

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Description

6-Chloro-5-nitro-3-pyridinecarboxylic acid features a pyridine core functionalized with electron-withdrawing chlorine and nitro groups, enhancing its reactivity in cross-coupling and cyclization processes. This bench-stable derivative delivers high regioselectivity in synthetic routes to bioactive heterocycles.

Application

6-Chloro-5-nitro-3-pyridinecarboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal functional groups—chloro, nitro, and carboxylic acid—facilitate sequential transformations under mild conditions, supporting modular diversification in medicinal chemistry campaigns. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for scalable synthetic workflows.

General Information

CAS No. 7477-10-3
Cat. No. CS-W008886
Purity ≥95%
MDL No. MFCD09027297
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClN₂O₄
Molecular Weight 202.55
Synonym(s) NSC 404695; 6-Chloro-5-nitronicotinic acid
SMILES O=C(C1=CC([N+]([O-])=O)=C(Cl)N=C1)O

Computational Chemistry Data

TPSA 93.33
LogP 1.3414
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-5-nitro-3-pyridinecarboxylic acid

CAS No. 7477-10-3

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