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Structure of 74840-34-9
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4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid is a heterocyclic building block featuring a chlorine atom at C4, a methylthio group at C2, and a carboxylic acid at C5. This combination delivers enhanced electrophilicity and solubility in polar solvents, enabling efficient coupling reactions in medicinal chemistry applications. The molecule exhibits bench-stable handling under standard conditions.
4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and coupling reactions. The chloro group facilitates C–N and C–C bond formation under standard conditions, while the carboxylic acid enables amide coupling or esterification for downstream derivatization. The methylthio substituent provides orthogonal reactivity and enhances metabolic stability in target molecules. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of bioactive intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: