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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

  • CAS No. 74901-69-2

  • Cat. No. CS-W006561
  • Purity≥98%
  • MDL No.MFCD11109461
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine|CS-W006561

Structure of 74901-69-2

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Description

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine is a heterocyclic scaffold featuring dual chlorine substituents and a saturated thiophene fusion, enabling enhanced electron-withdrawing character. This structure integrates readily into kinase inhibitor frameworks and serves as a key building block in medicinal chemistry for targeted covalent drug design.

Application

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to thienopyrimidine scaffolds prevalent in medicinal chemistry. Its dichloro substitution pattern facilitates nucleophilic aromatic substitution, allowing straightforward functionalization at C2 and C4 positions. The saturated thiophene ring enhances stability and solubility, supporting robust performance in standard coupling reactions and scalable process development.

General Information

  • CAS No. 74901-69-2
  • Cat. No. CS-W006561
  • Purity ≥98%
  • MDL No. MFCD11109461
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂N₂S
  • Molecular Weight 207.08
  • Synonym(s) None
  • SMILES ClC1=C2C(CCS2)=NC(Cl)=N1

Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.4316
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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