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Structure of 75092-25-0
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Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate features a reactive iodine handle at the 4-position, enabling efficient cross-coupling transformations. The electron-deficient pyrazole core enhances stability and facilitates selective functionalization. This bench-stable reagent integrates seamlessly into synthetic workflows requiring heterocyclic building blocks with orthogonal reactivity.
Methyl 4-iodo-1-methyl-1H-pyrazole-3-carboxylate serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted pyrazole scaffolds. The iodide group facilitates palladium-catalyzed coupling with aryl, heteroaryl, and alkenyl boranes or stannanes under standard conditions. Its methyl ester functionality offers stability and compatibility with common protecting group strategies. The molecule exhibits robust bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: