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Structure of 753-89-9
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1-Chloro-2,2-dimethylpropane was used as a substrate to perform the quantum mechanics calculations on LinB (a 33-kDa haloalkane dehalogenase from Sphingomonas paucimobilis UT26) to study which active site conformations and protonation states were eligible to result in catalysis.
1-Chloro-2,2-dimethylpropane serves as a stable, bench-ready alkylating agent for nucleophilic substitution reactions. Its tertiary chloride functionality enables efficient SN2 reactions with amines, thiols, and enolates under mild conditions. The neopentyl structure provides enhanced resistance to elimination, facilitating clean functionalization in complex molecule synthesis. This reagent functions reliably in the construction of alkylated heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS02,GHS07,GHS08
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H225-H302-H317-H334
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P272-P280-P284-P302+P352-P303+P361+P353-P304+P340-P330-P362+P364-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: