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CS-W001157 4
Total: USD 88.00

Fludarabine phosphate

  • CAS No. 75607-67-9

  • Cat. No. CS-0861
  • Purity≥98%
  • MDL No.MFCD00866418

*For research and further manufacturing use only, not for direct human use.

Fludarabine phosphate|CS-0861

Structure of 75607-67-9

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General Information

  • CAS No. 75607-67-9
  • Cat. No. CS-0861
  • Purity ≥98%
  • MDL No. MFCD00866418
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃FN₅O₇P
  • Molecular Weight 365.21
  • Synonym(s) NSC 118218 (phosphate)
  • SMILES NC1=C2C(N([C@H]3[C@@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)C=N2)=NC(F)=N1

Description

Polynucleotide involved in protein synthesis. Found in both the nucleus and the cytoplasm of cells.

Application

Fludarabine (phosphate) serves as a prodrug precursor enabling intracellular delivery of fludarabine, a purine nucleoside analog with established utility in purine metabolism inhibition. Its phosphate ester functionality facilitates enzymatic activation to the active 5'-monophosphate form, supporting consistent incorporation into DNA during replication. The compound exhibits bench stability and compatibility with standard nucleoside synthesis workflows, facilitating use in the construction of antimetabolite scaffolds for oncology research.

Synthesis

  • Route1

    References

    • ADORKEM TECHNOLOGY SPA Patent: WO2005/40183 A2, 2005 ; Location in patent: Page/Page column 4-5 ;
  • Route2

    References

    • US5296589 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H341-H361
Precautionary Statements : P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   186.07
  • LogP   -1.7239
  • H_Acceptors   10
  • H_Donors   5
  • Rotatable_Bonds   4

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