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CS-W001157 4
Total: USD 88.00

6-(Methoxycarbonyl)-2-naphthoic acid

  • CAS No. 7568-08-3

  • Cat. No. CS-0132199
  • Molecule weight230.22
  • Purity≥95%
  • MDL No.MFCD00805122

*For research and further manufacturing use only, not for direct human use.

6-(Methoxycarbonyl)-2-naphthoic acid|CS-0132199

Structure of 7568-08-3

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General Information

  • CAS No. 7568-08-3
  • Cat. No. CS-0132199
  • Purity ≥95%
  • MDL No. MFCD00805122
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀O₄
  • Molecular Weight 230.22
  • Synonym(s) 6-(METHOXYCARBONYL)NAPHTHALENE-2-CARBOXYLIC ACID
  • SMILES O=C(C1=CC=C2C=C(C(O)=O)C=CC2=C1)OC

Description

6-(Methoxycarbonyl)-2-naphthoic acid features a naphthoic acid core with a methoxycarbonyl group at the 6-position, enabling direct integration into synthetic routes requiring electron-deficient aromatic carboxylates. This bench-stable derivative facilitates coupling reactions and serves as a key scaffold in medicinal chemistry and materials synthesis.

Application

6-(Methoxycarbonyl)-2-naphthoic acid serves as a versatile building block for naphthoic acid derivatives, enabling direct functionalization at the C6 position. Its carboxylic acid and ester groups offer orthogonal reactivity, facilitating amidation, reduction, or coupling reactions in synthetic sequences. The molecule exhibits good bench stability and is readily purified by recrystallization, supporting its use in the construction of heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L. Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
  • Route2

    References

    • Green; Simpson; Zhou; Ho; Blough Journal of the American Chemical Society, 1990 , vol. 112, # 20 p. 7337 - 7346
  • Route3

    References

    • Green; Simpson; Zhou; Ho; Blough Journal of the American Chemical Society, 1990 , vol. 112, # 20 p. 7337 - 7346

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.6
  • LogP   2.3246
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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