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CS-W001157 4
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1-Methyl-1H-indazol-5-ol

  • CAS No. 756839-14-2

  • Cat. No. CS-W019794
  • Purity≥98%
  • MDL No.MFCD11869778

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-indazol-5-ol|CS-W019794

Structure of 756839-14-2

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General Information

  • CAS No. 756839-14-2
  • Cat. No. CS-W019794
  • Purity ≥98%
  • MDL No. MFCD11869778
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 1H-Indazol-5-ol, 1-methyl- (9CI)
  • SMILES OC1=CC2=C(N(C)N=C2)C=C1

Description

1-Methyl-1H-indazol-5-ol features a fused bicyclic core with a phenolic hydroxyl and methylated nitrogen, conferring enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for kinase inhibitors and CNS-targeted therapeutics.

Application

1-Methyl-1H-indazol-5-ol serves as a versatile building block for medicinal chemistry, enabling direct functionalization at the C5 position via palladium-catalyzed cross-coupling reactions. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient access to substituted indazoles. The molecule functions as a key scaffold in the synthesis of bioactive heterocycles, particularly in kinase inhibitor development.

Synthesis

  • Route1

    References

    • WO2004/108663 A1, ; Page 106-107 ;
  • Route2
    • 5-Methoxy-1-methyl-1H-indazole|CS-0469067
      756839-44-8
    • ~%
    • In-stock
      1-Methyl-1H-indazol-5-ol|CS-W019794
      756839-14-2

    References

    • US2004/180896 A1, ; US 20040180896 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.2789
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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