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Structure of 76196-80-0
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Methyl 5-methylpyrimidine-2-carboxylate features a pyrimidine core bearing a methyl group at the 5-position and a carboxylate ester at the 2-position, offering a robust scaffold for medicinal chemistry. The electron-deficient heterocycle facilitates transition metal-catalyzed functionalization, while the methyl substituent enhances lipophilicity and metabolic stability. This compound serves as a key intermediate in synthesizing antiviral agents and kinase inhibitors, integrating readily into diverse coupling reactions under standard conditions.
Methyl 5-methylpyrimidine-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds prevalent in medicinal chemistry. Its methyl and ester functionalities offer orthogonal handles for selective derivatization, while the electron-deficient pyrimidine ring facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and is amenable to purification by standard chromatographic methods, making it well-suited for iterative synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: