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CS-W001157 4
Total: USD 88.00

4-(1H-Pyrazol-1-yl)piperidine

  • CAS No. 762240-09-5

  • Cat. No. CS-W019213
  • Purity≥95%
  • MDL No.MFCD09998987

*For research and further manufacturing use only, not for direct human use.

4-(1H-Pyrazol-1-yl)piperidine|CS-W019213

Structure of 762240-09-5

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General Information

  • CAS No. 762240-09-5
  • Cat. No. CS-W019213
  • Purity ≥95%
  • MDL No. MFCD09998987
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃N₃
  • Molecular Weight 151.21
  • Synonym(s) Piperidine,4-(1H-pyrazol-1-yl)
  • SMILES C1(N2N=CC=C2)CCNCC1

Description

4-(1H-Pyrazol-1-yl)piperidine features a pyrazole ring tethered to a piperidine scaffold, delivering a polar, nitrogen-rich pharmacophore. This combination enables strong hydrogen bonding and enhanced solubility, facilitating integration into bioactive molecules. The compound serves as a key building block in medicinal chemistry for targeting G-protein-coupled receptors and kinase pathways.

Application

4-(1H-Pyrazol-1-yl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization protocols. Its pyrazole-piperidine scaffold offers favorable solubility, metabolic stability, and compatibility with common reaction conditions, facilitating efficient synthesis of target molecules in drug discovery campaigns.

Synthesis

  • Route1
    • 4-(1H-Pyrazol-1-yl)pyridine|CS-0308307
      25700-13-4
    • ~80%
    • In-stock
      4-(1H-Pyrazol-1-yl)piperidine|CS-W019213
      762240-09-5

    References

    • Shevchuk, Nadiia V.; Liubchak, Kostiantyn; Nazarenko, Kostiantyn G.; Yurchenko, Aleksandr A.; Volochnyuk, Dmitriy M.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A. Synthesis (Germany), 2012 , vol. 44, # 13 art. no. SS-2012-Z0299-OP, p. 2041 - 2048
  • Route2

    References

    • WO2013/10453 A1, ; Page/Page column 95 ;
  • Route3
    • null|null
      1120-87-2
    • ~%
    • In-stock
      4-(1H-Pyrazol-1-yl)piperidine|CS-W019213
      762240-09-5

    References

    • Synthesis (Germany), , vol. 44, # 13 art. no. SS-2012-Z0299-OP, p. 2041 - 2048

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   0.8076
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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