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Structure of 7648-30-8
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Ethyl 2,2-difluoro-2-iodoacetate is a fluorinated α-haloester featuring a trifunctional carbon center bearing ethoxy, difluoro, and iodo substituents. This electrophilic reagent integrates readily into synthetic sequences requiring dual fluorination and iodine-mediated coupling. The molecule exhibits enhanced stability under standard conditions while maintaining high reactivity in transition-metal-catalyzed transformations.
Ethyl 2,2-difluoro-2-iodoacetate serves as a versatile electrophilic building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its α-iodo carbonyl functionality enables efficient palladium-catalyzed cross-coupling reactions and facilitates nucleophilic substitution under mild conditions. The geminal difluoro substitution enhances metabolic stability and modulates electronic properties, making it valuable in medicinal chemistry applications. Bench-stable and readily handled, it offers predictable reactivity in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H302-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: