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2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

  • CAS No. 766545-20-4

  • Cat. No. CS-D0309
  • Purity≥96%
  • MDL No.MFCD09835503

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride|CS-D0309

Structure of 766545-20-4

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General Information

  • CAS No. 766545-20-4
  • Cat. No. CS-D0309
  • Purity ≥96%
  • MDL No. MFCD09835503
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀Cl₂N₂
  • Molecular Weight 205.08
  • Synonym(s) 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridinehydrochloride
  • SMILES ClC1=NC2=C(CNCC2)C=C1.Cl

Description

This bench-stable heterocyclic salt features a chlorinated tetrahydronaphthyridine core, enabling direct incorporation into medicinal chemistry campaigns. The hydrochloride form enhances solubility and crystallinity, streamlining purification and handling in synthetic workflows.

Application

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its bench-stable hydrochloride salt form facilitates handling and purification, while the tetrahydro-1,6-naphthyridine core provides a rigid, bioisostatic scaffold for drug discovery applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.8025
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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