3-(Trifluoromethyl)thiophene-2-carboxylic acid

Name: 3-(Trifluoromethyl)thiophene-2-carboxylic acid
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CAS No. 767337-59-7
Cat. No. CS-W021784
Purity≥98%
MDL No.MFCD20657880

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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3-(Trifluoromethyl)thiophene-2-carboxylic acid|CS-W021784

Structure of 767337-59-7

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General Information

CAS No. 767337-59-7
Cat. No. CS-W021784
Purity ≥98%
MDL No. MFCD20657880
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃F₃O₂S
Molecular Weight None
Synonym(s) None
SMILES O=C(C1=C(C(F)(F)F)C=CS1)O

Description

3-(Trifluoromethyl)thiophene-2-carboxylic acid features a trifluoromethyl group positioned ortho to the carboxylic acid on a thiophene scaffold, delivering enhanced electron-withdrawing character and metabolic stability. This structural motif enables direct incorporation into bioactive scaffolds, particularly in kinase inhibitors and pharmaceutical intermediates where lipophilicity and target affinity are critical. The molecule exhibits robust bench stability and compatibility with standard coupling protocols.

Application

3-(Trifluoromethyl)thiophene-2-carboxylic acid serves as a versatile building block for bioactive heterocycles, enabling efficient access to thiophene-based pharmaceutical scaffolds. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the carboxylic acid functionality facilitates direct amidation, esterification, or coupling reactions. The compound exhibits excellent bench stability and is compatible with standard synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 37.3
LogP 2.4651
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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3-(Trifluoromethyl)thiophene-2-carboxylic acid

CAS No. 767337-59-7

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