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CS-W001157 4
Total: USD 88.00

2-Methyl-1,5-naphthyridine

  • CAS No. 7675-32-3

  • Cat. No. CS-0021495
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD07437992

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1,5-naphthyridine|CS-0021495

Structure of 7675-32-3

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General Information

  • CAS No. 7675-32-3
  • Cat. No. CS-0021495
  • Purity ≥97%
  • MDL No. MFCD07437992
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂
  • Molecular Weight None
  • Synonym(s) 2-Methyl-1,5-naphthyridine; 2-Methyl-1,5-diazanaphthalene
  • SMILES CC1=NC2=CC=CN=C2C=C1

Description

2-Methyl-1,5-naphthyridine features a fused bicyclic core with a methyl substituent at the 2-position, conferring enhanced electron density and improved solubility in organic media. This structural motif serves as a robust scaffold for ligand design in transition metal catalysis and functional materials development.

Application

2-Methyl-1,5-naphthyridine serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its electron-deficient aromatic core facilitates palladium-catalyzed cross-coupling reactions and enables direct functionalization at the 3- and 4-positions. The methyl group enhances solubility and provides a handle for oxidation or further derivatization, while the scaffold exhibits good bench stability and compatibility with common protecting groups.

Synthesis

  • Route1
    • null|null
      80287-53-2
    • In-stock
      Glycerol|CS-6964
      56-81-5
    • ~56%
    • In-stock
      2-Methyl-1,5-naphthyridine|CS-0021495
      7675-32-3

    References

    • Gellibert, Francoise; Woolven, James; Fouchet, Marie-Helene; Mathews, Neil; Goodland, Helen; Lovegrove, Victoria; Laroze, Alain; Nguyen, Van-Loc; Sautet, Stephane; Wang, Ruolan; Janson, Cheryl; Smith, Ward; Krysa, Gael; Boullay, Valerie; De Gouville, Anne-Charlotte; Huet, Stephane; Hartley, David Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4494 - 4506
  • Route2
    • 2-Chloro-6-methyl-1,5-naphthyridine|CS-0100026
      764717-61-5
    • ~%
    • In-stock
      2-Methyl-1,5-naphthyridine|CS-0021495
      7675-32-3

    References

    • Yakugaku Zasshi, , vol. 62, p. 257,265; dtsch. Ref. S. 66 Chem.Abstr., , p. 2950
  • Route3
    • 6-Methyl-1,5-naphthyridin-2-ol|CS-0720279
      764717-60-4
    • ~%
    • In-stock
      2-Methyl-1,5-naphthyridine|CS-0021495
      7675-32-3

    References

    • Yakugaku Zasshi, , vol. 62, p. 257,265; dtsch. Ref. S. 66 Chem.Abstr., , p. 2950

Safety Information

Download SDS
GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.93822
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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