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CS-W001157 4
Total: USD 88.00

1-(4-Bromophenyl)-2,2,2-trifluoroethanol

  • CAS No. 76911-73-4

  • Cat. No. CS-M1425
  • Purity≥98%
  • MDL No.MFCD12786801

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromophenyl)-2,2,2-trifluoroethanol|CS-M1425

Structure of 76911-73-4

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General Information

  • CAS No. 76911-73-4
  • Cat. No. CS-M1425
  • Purity ≥98%
  • MDL No. MFCD12786801
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrF₃O
  • Molecular Weight 255.03
  • Synonym(s) 1-(4-bromophenyl)-2,2,2-trifluoroethan-1-ol
  • SMILES BrC1=CC=C(C=C1)C(C(F)(F)F)O

Description

1-(4-Bromophenyl)-2,2,2-trifluoroethanol features a brominated aromatic ring paired with a trifluoromethyl-bearing alcohol, delivering enhanced lipophilicity and metabolic stability. This combination enables direct incorporation into bioactive scaffolds, particularly in pharmaceutical intermediates requiring halogen-directed functionalization or fluorinated pharmacophores.

Application

1-(4-Bromophenyl)-2,2,2-trifluoroethanol serves as a versatile building block in medicinal chemistry and materials science, enabling efficient C–C and C–heteroatom bond formation. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the bromophenyl moiety facilitates palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for iterative synthesis of complex aryl-functionalized scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   3.0448
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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