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CS-W001157 4
Total: USD 88.00

1-(4-Fluorophenyl)cyclopropanecarboxylic acid

  • CAS No. 773100-29-1

  • Cat. No. CS-W018962
  • Purity≥96%
  • MDL No.MFCD06208777

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluorophenyl)cyclopropanecarboxylic acid|CS-W018962

Structure of 773100-29-1

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General Information

  • CAS No. 773100-29-1
  • Cat. No. CS-W018962
  • Purity ≥96%
  • MDL No. MFCD06208777
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉FO₂
  • Molecular Weight 180.18
  • Synonym(s) 1-(4-FLUORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
  • SMILES O=C(C1(C2=CC=C(F)C=C2)CC1)O

Description

1-(4-Fluorophenyl)cyclopropanecarboxylic acid features a rigid cyclopropane ring fused to a para-fluorinated phenyl group, delivering enhanced metabolic stability and targeted bioactivity. This structural motif integrates seamlessly into pharmaceutical scaffolds, enabling efficient coupling in medicinal chemistry campaigns.

Application

1-(4-Fluorophenyl)cyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its cyclopropyl carboxylic acid motif provides enhanced metabolic stability and conformational rigidity, while the 4-fluorophenyl group offers favorable electronic properties and lipophilicity. The compound exhibits bench stability, facilitates straightforward purification, and demonstrates broad compatibility with amide formation, Suzuki coupling, and other common transformations in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9419
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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