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Structure of 77326-46-6
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Methyl 2-cyano-3-nitrobenzoate features a conjugated cyano and nitro group flanking a methyl ester, delivering high reactivity in transition-metal-catalyzed couplings. This electron-deficient aromatic scaffold enables efficient incorporation into complex heterocycles and serves as a robust building block for pharmaceutical intermediates under standard conditions.
Methyl 2-cyano-3-nitrobenzoate serves as a versatile synthon in heterocyclic synthesis, enabling efficient access to substituted quinoline and benzimidazole scaffolds via tandem cyclization reactions. The ortho-difunctionalized aromatic core exhibits excellent bench stability and facilitates straightforward purification. Its dual electron-withdrawing groups (cyano and nitro) enhance electrophilicity for nucleophilic substitution and enable compatibility with palladium-catalyzed coupling protocols. Functions reliably in multi-step sequences requiring functional group tolerance and predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: