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CS-W001157 4
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Imidazo[2,1-b]thiazole-2-carboxylic acid

  • CAS No. 773841-78-4

  • Cat. No. CS-0043803
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Imidazo[2,1-b]thiazole-2-carboxylic acid|CS-0043803

Structure of 773841-78-4

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General Information

  • CAS No. 773841-78-4
  • Cat. No. CS-0043803
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O₂S
  • Molecular Weight 168.17
  • Synonym(s) Imidazo[2,1-b]thiazole-2-carboxylicacid
  • SMILES OC(=O)C1=CN2C=CN=C2S1

Description

Imidazo[2,1-b]thiazole-2-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 2-position, enabling direct conjugation in bioactive molecule design. This scaffold combines enhanced solubility with metabolic stability, facilitating integration into pharmaceutical candidates requiring precise spatial orientation and hydrogen-bonding capacity.

Application

Imidazo[2,1-b]thiazole-2-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive scaffolds through standard amide coupling and derivatization protocols. Its carboxylic acid functionality facilitates conjugation with amines and nucleophiles, while the fused imidazo-thiazole core provides structural rigidity and enhanced metabolic stability. The compound exhibits bench-stable handling characteristics and is compatible with common purification methods, making it well-suited for iterative synthesis campaigns in drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.6
  • LogP   1.094
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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