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Structure of 773869-57-1
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5-(Hydroxymethyl)-2-iodophenol features a phenolic hydroxyl group paired with a para-iodinated aromatic ring and a reactive hydroxymethyl side chain. This trifunctional scaffold enables direct coupling in cross-coupling reactions, bioconjugation, or polymer functionalization under mild conditions. The iodide serves as a versatile handle for palladium-catalyzed transformations, while the hydroxymethyl moiety supports derivatization via oxidation or etherification. The molecule exhibits good stability and solubility in common organic solvents, facilitating use in synthetic workflows requiring precise functional group control.
5-(Hydroxymethyl)-2-iodophenol serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. The ortho-iodo and hydroxymethyl groups enable palladium-catalyzed cross-coupling reactions and selective derivatization, while the phenolic OH supports further functionalization. Its bench-stable nature and compatibility with standard protecting group strategies facilitate efficient synthetic planning in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: