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Structure of 773874-13-8
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Methyl 5-bromo-2-(trifluoromethoxy)benzoate features a bromine atom at the 5-position and a trifluoromethoxy group at the 2-position on a methyl benzoate scaffold. This electron-deficient aryl halide enables efficient palladium-catalyzed cross-coupling reactions, delivering complex aromatic architectures with high functional group tolerance under standard conditions.
Methyl 5-bromo-2-(trifluoromethoxy)benzoate serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to biaryl and heteroaryl scaffolds. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the trifluoromethoxy moiety imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for modular synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: