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CS-W001157 4
Total: USD 88.00

5,6-Difluoroindoline-2,3-dione

  • CAS No. 774-47-0

  • Cat. No. CS-W002978
  • Purity≥97%
  • MDL No.MFCD02998377
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoroindoline-2,3-dione|CS-W002978

Structure of 774-47-0

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Description

5,6-Difluoroindoline-2,3-dione features a highly electron-deficient fused ring system with fluorine substituents at the 5 and 6 positions, enhancing its reactivity in cycloaddition and coupling processes. This bench-stable, moisture-tolerant heterocycle integrates readily into complex molecular architectures, offering precise control over regiochemistry and electronic properties in synthetic applications.

Application

5,6-Difluoroindoline-2,3-dione serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds through standard cycloaddition and electrophilic substitution reactions. Its electron-deficient core facilitates efficient coupling with nucleophiles, while the difluoro substitution enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis campaigns in API development.

General Information

  • CAS No. 774-47-0
  • Cat. No. CS-W002978
  • Purity ≥97%
  • MDL No. MFCD02998377
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₃F₂NO₂
  • Molecular Weight 183.11
  • Synonym(s) skln-0003
  • SMILES O=C1Nc2c(C1=O)cc(c(c2)F)F

Computational Chemistry Data

  • TPSA   46.17
  • LogP   1.0996
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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