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CS-W001157 4
Total: USD 88.00

Diethoxymethylphenylsilane

  • CAS No. 775-56-4

  • Cat. No. CS-W020892
  • Purity≥96%
  • MDL No.MFCD00048541

*For research and further manufacturing use only, not for direct human use.

Diethoxymethylphenylsilane|CS-W020892

Structure of 775-56-4

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General Information

  • CAS No. 775-56-4
  • Cat. No. CS-W020892
  • Purity ≥96%
  • MDL No. MFCD00048541
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈O₂Si
  • Molecular Weight 210.34
  • Synonym(s) Methylphenyldiethoxysilane
  • SMILES C[Si](OCC)(C1=CC=CC=C1)OCC

Description

Diethoxymethylphenylsilane features a methylphenylsilane core with two ethoxy groups, enabling controlled hydrolysis and condensation. This functionality supports robust siloxane bond formation in surface modification and sol-gel applications, delivering durable, moisture-resistant coatings with predictable reactivity under standard conditions.

Application

Diethoxymethylphenylsilane serves as a stable, bench-ready silyl protecting group for alcohols and carboxylic acids, enabling orthogonal protection in complex molecule synthesis. Its mild deprotection conditions and compatibility with a broad range of functional groups facilitate efficient late-stage modifications. The molecule functions as a versatile building block in the construction of silicon-containing heterocycles and bioactive scaffolds, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Synthesis

  • Route1
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      64-17-5
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      766-08-5
    • ~90%
    • Diethoxymethylphenylsilane|CS-W020892
      775-56-4

    References

    • Lorenz, Catrin; Schubert, Ulrich Chemische Berichte, 1995 , vol. 128, # 12 p. 1267 - 1270
  • Route2
    • null|null
      98-13-5
    • ~%
    • Diethoxymethylphenylsilane|CS-W020892
      775-56-4

    References

    • Journal of the American Chemical Society, , vol. 70, p. 3590 - 3596
  • Route3
    • null|null
      2031-67-6
    • ~%
    • Diethoxymethylphenylsilane|CS-W020892
      775-56-4

    References

    • Journal of the American Chemical Society, , vol. 74, p. 386 - 390

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.0386
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   5

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