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CS-W001157 4
Total: USD 88.00

1-Benzoylpiperidine

  • CAS No. 776-75-0

  • Cat. No. CS-0014481
  • Purity≥98%
  • MDL No.MFCD00023702

*For research and further manufacturing use only, not for direct human use.

1-Benzoylpiperidine|CS-0014481

Structure of 776-75-0

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General Information

  • CAS No. 776-75-0
  • Cat. No. CS-0014481
  • Purity ≥98%
  • MDL No. MFCD00023702
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO
  • Molecular Weight 189.25
  • Synonym(s) Protectine I; α-Repellin; Phenyl(piperidin-1-yl)methanone
  • SMILES O=C(N1CCCCC1)C2=CC=CC=C2

Description

1-Benzoylpiperidine features a piperidine core functionalized with a benzoyl group, delivering enhanced lipophilicity and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, serving as a key building block for CNS-targeted compounds and bioactive molecules requiring balanced membrane permeability and solubility.

Application

1-Benzoylpiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization pathways. Its benzoyl group provides steric and electronic modulation, while the piperidine core offers a readily derivatizable nitrogen for amide formation, alkylation, or reduction. The compound exhibits good bench stability and facilitates purification via crystallization, making it well-suited for scalable synthesis and intermediate development in API research.

Synthesis

  • Route1
    • null|null
      110-89-4
    • In-stock
      Iodobenzene|CS-W008603
      591-50-4
    • null|null
      201230-82-2
    • ~79%
    • In-stock
      1-Benzoylpiperidine|CS-0014481
      776-75-0

    References

    • Mei, Hui; Hu, Jianglin; Xiao, Se; Lei, Yizhu; Li, Guangxing Applied Catalysis A: General, 2014 , vol. 475, p. 40 - 47
  • Route2
    • null|null
      110-89-4
    • In-stock
      N-Benzoylimidazole|CS-W017598
      10364-94-0
    • ~94%
    • In-stock
      1-Benzoylpiperidine|CS-0014481
      776-75-0

    References

    • Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2373 - 2376
  • Route3
    • null|null
      110-89-4
    • null|null
      98-88-4
    • ~10%
    • In-stock
      1-Benzoylpiperidine|CS-0014481
      776-75-0

    References

    • Barbe, Guillaume; Charette, Andre B. Journal of the American Chemical Society, 2008 , vol. 130, # 1 p. 18 - 19

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   2.3127
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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