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CS-W001157 4
Total: USD 88.00

2,3-Dihydrophenanthren-4(1H)-one

  • CAS No. 778-48-3

  • Cat. No. CS-W015702
  • Molecule weight196.25
  • Purity≥98%
  • MDL No.MFCD00028857

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydrophenanthren-4(1H)-one|CS-W015702

Structure of 778-48-3

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General Information

  • CAS No. 778-48-3
  • Cat. No. CS-W015702
  • Purity ≥98%
  • MDL No. MFCD00028857
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂O
  • Molecular Weight 196.25
  • Synonym(s) 1,2,3,4-Tetrahydrophenanthren-4-one
  • SMILES O=C1CCCC2=C1C3=C(C=C2)C=CC=C3

Description

2,3-Dihydrophenanthren-4(1H)-one is a polycyclic ketone featuring a fused tricyclic core with a labile enolizable carbonyl. This scaffold integrates readily into synthetic routes targeting bioactive molecules, offering enhanced solubility and stability under standard conditions.

Application

2,3-Dihydrophenanthren-4(1H)-one serves as a versatile scaffold for the synthesis of polycyclic aromatic compounds and natural product analogs. Its ketone functionality enables direct use in Grignard additions, reductions, and reductive amination workflows. The partially saturated ring system offers enhanced solubility and stability compared to fully aromatic analogs, facilitating purification and handling in multistep syntheses. Functions effectively as a building block in medicinal chemistry campaigns targeting CNS-active molecules and kinase inhibitors.

Synthesis

  • Route1
    • null|null
      845777-10-8
    • ~80%
    • null|null
      54784-07-5
    • In-stock
      2,3-Dihydrophenanthren-4(1H)-one|CS-W015702
      778-48-3

    References

    • Organic Letters, , vol. 9, # 22 p. 4639 - 4642
  • Route2

    References

    • Wiznycia, Alexander V.; Desper, John; Levy, Christopher J. Chemical Communications, 2005 , # 37 p. 4693 - 4695
  • Route3
    • null|null
      845777-10-8
    • ~88%
    • null|null
      521-66-4
    • null|null
      54784-07-5
    • In-stock
      2,3-Dihydrophenanthren-4(1H)-one|CS-W015702
      778-48-3

    References

    • Organic Letters, , vol. 9, # 22 p. 4639 - 4642

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P261-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.3588
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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