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Structure of 78060-54-5
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2-Chloroquinoline-6-carbonitrile features a quinoline scaffold with strategically positioned chlorine and nitrile groups, enabling efficient integration into pharmaceutical and agrochemical scaffolds. The electron-deficient ring system facilitates coupling reactions, while the nitrile moiety offers versatility in downstream functionalization. This compound exhibits robust stability under standard conditions and serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive heterocycles.
2-Chloroquinoline-6-carbonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 2-position via palladium-catalyzed cross-coupling. Its electron-deficient quinoline core and orthogonal nitrile group facilitate selective transformations, while the chloro substituent supports further derivatization through nucleophilic substitution or metal-catalyzed coupling. The compound exhibits good bench stability and is readily purified by flash chromatography, making it well-suited for scalable synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: