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CS-W001157 4
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4-(Furan-2-ylmethyl)thiomorpholine 1,1-dioxide

  • CAS No. 79206-94-3

  • Cat. No. CS-0352253
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Furan-2-ylmethyl)thiomorpholine 1,1-dioxide|CS-0352253

Structure of 79206-94-3

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General Information

  • CAS No. 79206-94-3
  • Cat. No. CS-0352253
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO₃S
  • Molecular Weight 215.27
  • Synonym(s) 4-(Furan-2-ylmethyl)-1,4-thiazinane 1,1-dioxide
  • SMILES O=S1(CCN(CC2=CC=CO2)CC1)=O

Description

4-(Furan-2-ylmethyl)thiomorpholine 1,1-dioxide features a furan-containing side chain that enhances solubility and metabolic stability. This thiomorpholine derivative integrates a polar sulfone group, enabling effective engagement in hydrogen bonding and polarity modulation within bioactive scaffolds. Its bench-stable nature supports reliable use in synthetic medicinal chemistry workflows.

Application

4-(Furan-2-ylmethyl)thiomorpholine 1,1-dioxide serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to thiomorpholine-based scaffolds. Its furan-2-ylmethyl moiety provides a handle for further functionalization via electrophilic or transition-metal-catalyzed transformations. The sulfone group enhances solubility and metabolic stability, while the thiomorpholine core offers favorable conformational flexibility and hydrogen-bonding capacity. This compound exhibits excellent bench stability and is compatible with standard synthetic workflows, facilitating rapid exploration of structure–activity relationships in drug discovery programs.

Synthesis

  • Route1
    • In-stock
      1,4-Oxathiane 4,4-dioxide|CS-0128435
      107-61-9
    • null|null
      617-89-0
    • ~85%
    • In-stock
      4-(Furan-2-ylmethyl)thiomorpholine 1,1-dioxide|CS-0352253
      79206-94-3

    References

    • Asinger, Friedrich; Kaussen, Manfred; Gold-Martin, Irmgard; Saus, Alfons Monatshefte fuer Chemie, 1981 , vol. 112, p. 643 - 657

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.52
  • LogP   0.51
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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