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Structure of 79427-88-6
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2-Hydroxy-5-(trifluoromethyl)benzoic acid features a strategically positioned trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability. The ortho-hydroxyl moiety enables chelation and directs regioselective functionalization. This compound serves as a key scaffold in bioactive molecule design, particularly in pharmaceutical intermediates requiring polar, electron-deficient aromatic systems under standard bench conditions.
2-Hydroxy-5-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to bioactive heterocycles. Its ortho-hydroxyl and trifluoromethyl groups provide enhanced solubility, metabolic stability, and favorable electronic effects for downstream functionalization. The molecule exhibits excellent bench stability and facilitates direct coupling reactions, including amide formation and Suzuki-Miyaura cross-couplings, due to its robust functional group tolerance and straightforward purification profile.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: