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Structure of 79474-35-4
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2-Fluoro-4,5-dimethoxybenzoic acid features a fluorinated aromatic core with two methoxy groups positioned ortho to the carboxylic acid, enhancing electron donation and metabolic stability. This combination imparts high solubility in polar organic solvents and enables direct coupling in amide bond formation. The molecule's defined substitution pattern supports efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-penetrant compounds.
2-Fluoro-4,5-dimethoxybenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis. Its ortho-fluoro substitution enables enhanced metabolic stability and modulates electronic properties, while the 4,5-dimethoxy groups provide steric and electronic tuning for target engagement. The carboxylic acid functionality facilitates direct coupling reactions or derivatization into amides, esters, and other bioactive scaffolds. Bench-stable and readily purified by recrystallization, it functions efficiently in standard peptide coupling, Suzuki-Miyaura, and Ullmann-type transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: