7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

Name: 7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 799274-06-9
Cat. No. CS-0071007
Purity≥97%
MDL No.MFCD08461074

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride|CS-0071007

Structure of 799274-06-9

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General Information

CAS No. 799274-06-9
Cat. No. CS-0071007
Purity ≥97%
MDL No. MFCD08461074
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₁ClFN
Molecular Weight 187.64
Synonym(s) Isoquinoline, 7-fluoro-1,2,3,4-tetrahydro-, hydrochloride
SMILES FC1=CC2=C(C=C1)CCNC2.Cl

Description

7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a fluorinated aromatic ring fused to a saturated nitrogen-containing backbone. This structure integrates a potent electron-withdrawing fluorine at the 7-position, enhancing metabolic stability and modulating basicity for improved solubility in aqueous media. The hydrochloride salt form ensures high purity and ease of handling, enabling direct use in synthetic transformations, medicinal chemistry campaigns, and drug discovery workflows where precise electronic tuning is required.

Application

7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a valuable building block in medicinal chemistry, enabling efficient access to bioactive isoquinoline scaffolds. Its fluorinated aromatic system enhances metabolic stability and modulates electronic properties, while the protonated nitrogen facilitates salt formation for improved solubility and handling. The compound exhibits excellent functional group tolerance and reactivity in standard coupling and alkylation reactions, making it ideal for iterative synthesis of CNS-targeted candidates and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

TPSA 12.03
LogP 1.8932
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Tetrahydroisoquinoline compounds

Key Words

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7-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

CAS No. 799274-06-9

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