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CS-W001157 4
Total: USD 88.00

4-Nitrophenyl (2-(trimethylsilyl)ethyl) carbonate

  • CAS No. 80149-80-0

  • Cat. No. CS-0017956
  • Purity≥98%
  • MDL No.MFCD00042930

*For research and further manufacturing use only, not for direct human use.

4-Nitrophenyl (2-(trimethylsilyl)ethyl) carbonate|CS-0017956

Structure of 80149-80-0

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General Information

  • CAS No. 80149-80-0
  • Cat. No. CS-0017956
  • Purity ≥98%
  • MDL No. MFCD00042930
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₅Si
  • Molecular Weight 283.35
  • Synonym(s) TEOC-ONP 4-Nitrophenyl 2-(Trimethylsilyl)Ethyl Carbonate
  • SMILES O=C(OCC[Si](C)(C)C)OC1=CC=C([N+]([O-])=O)C=C1

Description

t-Boc-N-amido-PEG20-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Synthesis

  • Route1

    References

    • Kim, Sang Woong; Hong, Chang Yong; Lee, Koo; Lee, Eun Ju; Koh, Jong Sung Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 7 p. 735 - 738
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    References

    • Journal of Organic Chemistry, , vol. 48, # 9 p. 1539 - 1541

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07,GHS09
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H225-H315-H411
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P273-P280-P302+P352-P362+P364-P370+P378-P391-P501

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Computational Chemistry Data

  • TPSA   78.67
  • LogP   3.4484
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   5

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