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3,6-Diamino-10-methylacridinium chloride-3,6-acridinediamine mixt

  • CAS No. 8048-52-0

  • Cat. No. CS-6959
  • Molecule weight468.98
  • PurityCl,13.3-15.8%
  • MDL No.MFCD00064307

*For research and further manufacturing use only, not for direct human use.

3,6-Diamino-10-methylacridinium chloride-3,6-acridinediamine mixt|CS-6959

Structure of 8048-52-0

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General Information

  • CAS No. 8048-52-0
  • Cat. No. CS-6959
  • Purity Cl,13.3-15.8%
  • MDL No. MFCD00064307
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₅ClN₆
  • Molecular Weight 468.98
  • Synonym(s) Acriflavinium (chloride) 3,6-Acridinediamine mix
  • SMILES NC(C=C1)=CC(C1=C2)=NC3=C2C=CC(N)=C3.NC(C=C4)=CC(C4=C5)=[N+](C)C6=C5C=CC(N)=C6.[Cl-]

Description

Intercalating into viral RNA genomes, Acriflavine (CAS 8048-52-0) suppresses SARS-CoV-2 replication and inhibits papain-like protease activity in β-coronaviruses while stabilizing high molecular weight RNA for fluorescent visualization in leukemia research assays.

Application

Acriflavine (CAS 8048-52-0) fluorescently labels high molecular weight RNA with distinct excitation and emission profiles across solvents, peaking at λex = 416 nm and λem = 514 nm in water. It binds selectively to RNA structures. Researchers leverage this property for real-time tracking in nucleic acid dynamics, while its donor role with rhodamine 6G enables precise pH sensing in live-cell environments.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P273-P302+P352-P305+P351+P338

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Computational Chemistry Data

  • TPSA   120.85
  • LogP   1.5383
  • H_Acceptors   5
  • H_Donors   4
  • Rotatable_Bonds   0

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