Lot numbers can be found on the outside label of a product:
4-(tert-Butyl)-2-chloropyridine
-
CAS No. 81167-60-4
- Cat. No. CS-W022028
- Purity≥95%
- MDL No.MFCD12131129
*For research and further manufacturing use only, not for direct human use.
Structure of 81167-60-4
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 81167-60-4
- Cat. No. CS-W022028
- Purity ≥95%
- MDL No. MFCD12131129
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₂ClN
- Molecular Weight 169.65
- Synonym(s) 4-tert-butyl-2-chloropyridine
- SMILES ClC1=NC=CC(C(C)(C)C)=C1
Description
4-(tert-Butyl)-2-chloropyridine features a sterically hindered tert-butyl group at the 4-position and a chlorine atom at the 2-position of the pyridine ring. This electronic and steric profile enhances stability and directs regioselective functionalization in cross-coupling reactions. The molecule exhibits favorable solubility in organic solvents and maintains integrity under standard bench conditions, enabling reliable use in synthetic workflows involving heterocyclic scaffolds.
Application
4-(tert-Butyl)-2-chloropyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient functionalization at the 2-position via palladium-catalyzed cross-coupling reactions. The tert-butyl group provides steric bulk and enhanced bench stability, while the chloropyridine moiety offers high reactivity in Suzuki, Stille, and Negishi couplings. Its compatibility with diverse reaction conditions facilitates rapid access to substituted pyridine scaffolds relevant to pharmaceutical development.
Synthesis
-
Route1
-
23569-17-7 - ~80%
-
In-stock
81167-60-4
References
-
Fu, Ross; Bercaw, John E.; Labinger, Jay A. Organometallics, 2011 , vol. 30, # 24 p. 6751 - 6765
-
-
Route2
-
In-stock
3978-81-2 - ~%
-
In-stock
81167-60-4
References
-
ALMIRALL, S.A.; VIDAL JUAN, Bernat; FORNS BERENGUEL, Maria Pilar; CASTILLO MCQUADE, Marcos; ERRA SOLA, Montserrat; MIR CEPEDA, Marta Patent: WO2012/41476 A1, 2012 ; WO 2012/041476 A1
-
-
Route3
-
109-09-1
-
38442-51-2
- ~%
-
In-stock
81167-60-4
-
In-stock
97691-23-1
References
-
Russell, Glen A.; Guo, Deliang; Khanna, Rajive K. Journal of Organic Chemistry, 1985 , vol. 50, # 18 p. 3423 - 3425
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS05,GHS06,GHS08,GHS09
|
|
Signal Word : Danger
|
UN#: 2810
|
|
Class : 6.1
|
Packing Group : Ⅲ
|
|
Hazard Statements : H302-H311+H331-H315-H318-H335-H373-H411
|
|
|
Precautionary Statements : P260-P261-P262-P264-P270-P271-P272-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361-P363-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 3.0325
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 4-(tert-Butyl)-2-chloropyridine sigma4-(tert-Butyl)-2-chloropyridine manufacturer4-(tert-Butyl)-2-chloropyridine price4-(tert-Butyl)-2-chloropyridine structure4-(tert-Butyl)-2-chloropyridine SDSbuy 4-(tert-Butyl)-2-chloropyridine4-(tert-Butyl)-2-chloropyridine supplier4-(tert-Butyl)-2-chloropyridine uses4-(tert-Butyl)-2-chloropyridine molecular weightprice of 4-(tert-Butyl)-2-chloropyridine4-(tert-Butyl)-2-chloropyridine chemical name formula of 4-(tert-Butyl)-2-chloropyridine