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Structure of 81167-60-4
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4-(tert-Butyl)-2-chloropyridine features a sterically hindered tert-butyl group at the 4-position and a chlorine atom at the 2-position of the pyridine ring. This electronic and steric profile enhances stability and directs regioselective functionalization in cross-coupling reactions. The molecule exhibits favorable solubility in organic solvents and maintains integrity under standard bench conditions, enabling reliable use in synthetic workflows involving heterocyclic scaffolds.
4-(tert-Butyl)-2-chloropyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient functionalization at the 2-position via palladium-catalyzed cross-coupling reactions. The tert-butyl group provides steric bulk and enhanced bench stability, while the chloropyridine moiety offers high reactivity in Suzuki, Stille, and Negishi couplings. Its compatibility with diverse reaction conditions facilitates rapid access to substituted pyridine scaffolds relevant to pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS05,GHS06,GHS08,GHS09
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H311+H331-H315-H318-H335-H373-H411
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Precautionary Statements : P260-P261-P262-P264-P270-P271-P272-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361-P363-P501
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Lot numbers can be found on the outside label of a product: