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CS-W001157 4
Total: USD 88.00

4-(tert-Butyl)-2-chloropyridine

  • CAS No. 81167-60-4

  • Cat. No. CS-W022028
  • Purity≥95%
  • MDL No.MFCD12131129
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(tert-Butyl)-2-chloropyridine|CS-W022028

Structure of 81167-60-4

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Description

4-(tert-Butyl)-2-chloropyridine features a sterically hindered tert-butyl group at the 4-position and a chlorine atom at the 2-position of the pyridine ring. This electronic and steric profile enhances stability and directs regioselective functionalization in cross-coupling reactions. The molecule exhibits favorable solubility in organic solvents and maintains integrity under standard bench conditions, enabling reliable use in synthetic workflows involving heterocyclic scaffolds.

Application

4-(tert-Butyl)-2-chloropyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient functionalization at the 2-position via palladium-catalyzed cross-coupling reactions. The tert-butyl group provides steric bulk and enhanced bench stability, while the chloropyridine moiety offers high reactivity in Suzuki, Stille, and Negishi couplings. Its compatibility with diverse reaction conditions facilitates rapid access to substituted pyridine scaffolds relevant to pharmaceutical development.

General Information

  • CAS No. 81167-60-4
  • Cat. No. CS-W022028
  • Purity ≥95%
  • MDL No. MFCD12131129
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂ClN
  • Molecular Weight 169.65
  • Synonym(s) 4-tert-butyl-2-chloropyridine
  • SMILES ClC1=NC=CC(C(C)(C)C)=C1

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.0325
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311+H331-H315-H318-H335-H373-H411
Precautionary Statements : P260-P261-P262-P264-P270-P271-P272-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361-P363-P501

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