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Structure of 81294-10-2
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2-Ethynyl-5-methylthiophene features a conjugated ethynyl group directly attached to a methyl-substituted thiophene ring, enabling efficient coupling in cross-coupling and click chemistry applications. The electron-rich heterocycle enhances reactivity, while the terminal alkyne supports stable incorporation into complex molecular architectures under standard conditions.
2-Ethynyl-5-methylthiophene serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted thiophene scaffolds. Its conjugated alkyne functionality facilitates Sonogashira and Glaser-type couplings with high chemoselectivity, while the methylthio group provides moderate stability and compatibility with standard synthetic workflows. The molecule exhibits bench stability and is amenable to purification via flash chromatography, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS02
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H225-H315-H319-H335
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Precautionary Statements : P210-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: