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CS-W001157 4
Total: USD 88.00

1-Methyl-4-(trifluoromethyl)-1H-imidazole

  • CAS No. 81769-69-9

  • Cat. No. CS-0616670
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-4-(trifluoromethyl)-1H-imidazole|CS-0616670

Structure of 81769-69-9

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General Information

  • CAS No. 81769-69-9
  • Cat. No. CS-0616670
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅F₃N₂
  • Molecular Weight 150.10
  • Synonym(s) None
  • SMILES FC(C1=CN(C)C=N1)(F)F

Description

1-Methyl-4-(trifluoromethyl)-1H-imidazole features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability. This bench-stable heterocycle integrates readily into medicinal chemistry scaffolds, offering improved solubility and lipophilicity profiles for target-directed drug design.

Application

1-Methyl-4-(trifluoromethyl)-1H-imidazole serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its electron-deficient imidazole core enables reliable coupling reactions and facilitates functionalization at the 2-position. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the N-methyl substitution improves solubility and synthetic handling. This compound functions as a key scaffold for bioactive molecule development and is compatible with standard cross-coupling and electrophilic substitution protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.4389
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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