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CS-W001157 4
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δ-Hexalactone

  • CAS No. 823-22-3

  • Cat. No. CS-0015920
  • Molecule weight114.14
  • Purity≥98%
  • MDL No.MFCD00083574

*For research and further manufacturing use only, not for direct human use.

δ-Hexalactone|CS-0015920

Structure of 823-22-3

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General Information

  • CAS No. 823-22-3
  • Cat. No. CS-0015920
  • Purity ≥98%
  • MDL No. MFCD00083574
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) 5-Hexanolide
  • SMILES O=C1OC(CCC1)C

Description

(±)-5-Hexanolide is a chiral γ-lactone featuring a six-membered ring with a hydroxyl group at the C5 position. This structure imparts enhanced solubility in polar solvents and facilitates stereocontrolled synthesis of complex natural products. The compound serves as a key intermediate in fragrance and pharmaceutical development due to its stability under standard bench conditions.

Application

(±)-5-Hexanolide serves as a versatile lactone building block in synthetic organic chemistry, enabling efficient access to saturated heterocyclic frameworks. Its functional group compatibility facilitates downstream transformations such as reduction, nucleophilic addition, and selective derivatization. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows and the construction of complex molecular architectures in medicinal chemistry and natural product synthesis.

Synthesis

  • Route1

    References

    • Advanced Synthesis and Catalysis, , vol. 354, # 18 p. 3405 - 3408
  • Route2
    • null|null
      1120-72-5
    • ~96%
    • In-stock
      δ-Hexalactone|CS-0015920
      823-22-3

    References

    • Journal of Organic Chemistry, , vol. 61, # 1 p. 314 - 323
  • Route3
    • null|null
      505-03-3
    • ~10%
    • In-stock
      δ-Hexalactone|CS-0015920
      823-22-3

    References

    • Journal of Organic Chemistry, , vol. 66, # 25 p. 8573 - 8584

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.102
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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