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Structure of 82380-18-5
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2-Fluoro-4-hydroxybenzonitrile features a strategically positioned hydroxyl group and nitrile moiety on a fluorinated aromatic ring, enabling direct functionalization in pharmaceutical intermediates. The electron-withdrawing fluoro and nitrile groups enhance reactivity in nucleophilic substitution cascades, while the phenolic OH supports hydrogen bonding and solubility control. This combination delivers a robust scaffold for bioactive molecule synthesis under standard conditions.
2-Fluoro-4-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and nitrile groups. Its ortho-fluorine facilitates nucleophilic aromatic substitution, while the hydroxyl group allows for etherification or esterification under standard conditions. The compound exhibits good bench stability and is amenable to purification by recrystallization or column chromatography, making it well-suited for use in multi-step syntheses of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS05,GHS09
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Signal Word : Danger
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H318-H411
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Precautionary Statements : P264-P270-P273-P280-P305+P351+P338-P330-P391-P501
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Lot numbers can be found on the outside label of a product: