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CS-W001157 4
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5-Bromo-2-chlorobenzo[d]thiazole

  • CAS No. 824403-26-1

  • Cat. No. CS-0005545
  • Purity≥97%
  • MDL No.MFCD09749227
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chlorobenzo[d]thiazole|CS-0005545

Structure of 824403-26-1

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Description

5-Bromo-2-chlorobenzo[d]thiazole features a fused heterocyclic core with complementary halogen substituents enabling selective cross-coupling transformations. The bromine and chlorine atoms facilitate sequential functionalization, while the electron-deficient ring system enhances reactivity in palladium-catalyzed processes. This compound serves as a robust scaffold for constructing complex aromatic architectures under standard conditions.

Application

5-Bromo-2-chlorobenzo[d]thiazole serves as a versatile building block in medicinal chemistry and materials science, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-halogenated scaffold exhibits excellent bench stability, tolerates diverse functional groups, and facilitates modular synthesis of complex heterocyclic architectures. Its dual halogenation pattern supports sequential coupling strategies, making it ideal for constructing multi-substituted benzo[d]thiazole scaffolds relevant to kinase inhibitors and organic semiconductors.

General Information

  • CAS No. 824403-26-1
  • Cat. No. CS-0005545
  • Purity ≥97%
  • MDL No. MFCD09749227
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrClNS
  • Molecular Weight 248.53
  • Synonym(s) 5-BROMO-2-CHLOROBENZOTHIAZOLE
  • SMILES ClC1=NC2=CC(Br)=CC=C2S1

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.7122
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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