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CS-W001157 4
Total: USD 88.00

4-Methyl-2-phenyl-1H-imidazole

  • CAS No. 827-43-0

  • Cat. No. CS-W017956
  • Purity≥96%
  • MDL No.MFCD00047015

*For research and further manufacturing use only, not for direct human use.

4-Methyl-2-phenyl-1H-imidazole|CS-W017956

Structure of 827-43-0

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General Information

  • CAS No. 827-43-0
  • Cat. No. CS-W017956
  • Purity ≥96%
  • MDL No. MFCD00047015
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂
  • Molecular Weight 158.20
  • Synonym(s) 5-methyl-2-phenyl-1H-imidazole
  • SMILES CC1=CNC(C2=CC=CC=C2)=N1

Description

4-Methyl-2-phenyl-1H-imidazole is a bench-stable heterocyclic compound featuring a fused imidazole core with distinct electron-rich character. The methyl and phenyl substituents enhance solubility and structural rigidity, enabling efficient integration into catalytic systems and pharmaceutical scaffolds. This imidazole derivative serves as a robust building block in synthetic chemistry workflows requiring stable, functionalized nitrogen heterocycles.

Application

4-Methyl-2-phenyl-1H-imidazole serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate straightforward derivatization via electrophilic substitution or cross-coupling. The scaffold functions effectively in the synthesis of imidazole-based pharmaceuticals and agrochemicals, offering predictable reactivity and ease of purification in routine laboratory workflows.

Synthesis

  • Route1

    References

    • Lee, Dong-Hwan; Choi, Minkee; Yu, Byung-Woo; Ryoo, Ryong; Taher, Abu; Hossain, Shahin; Jin, Myung-Jong Advanced Synthesis and Catalysis, 2009 , vol. 351, # 17 p. 2912 - 2920
  • Route2
    • In-stock
      Benzamidine hydrochloride|CS-W019567
      1670-14-0
    • null|null
      67-64-1
    • ~63%
    • In-stock
      4-Methyl-2-phenyl-1H-imidazole|CS-W017956
      827-43-0

    References

    • John, Oliver R. S.; Killeen, Niall M.; Knowles, Deborah A.; Yau, Sze Chak; Bagley, Mark C.; Tomkinson, Nicholas C. O. Organic Letters, 2007 , vol. 9, # 20 p. 4009 - 4012
  • Route3
    • null|null
      88346-57-0
    • ~97%
    • In-stock
      4-Methyl-2-phenyl-1H-imidazole|CS-W017956
      827-43-0

    References

    • Watanabe, T.; Nishiyama, J.; Hirate, R.; Uehara, K.; Inoue, M.; et al. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1277 - 1281

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.38512
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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