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CS-W001157 4
Total: USD 88.00

3-Indolepropionic acid

  • CAS No. 830-96-6

  • Cat. No. CS-W015945
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD00005660

*For research and further manufacturing use only, not for direct human use.

3-Indolepropionic acid|CS-W015945

Structure of 830-96-6

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General Information

  • CAS No. 830-96-6
  • Cat. No. CS-W015945
  • Purity ≥97%
  • MDL No. MFCD00005660
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO₂
  • Molecular Weight None
  • Synonym(s) Indole-3-propionic acid; 3-IPA
  • SMILES C1=CC=CC2=C1C(=C[NH]2)CCC(O)=O

Description

3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded -amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.Reactant for preparation of:Fluorescent analogues of strigolactonesAnti-tumor agentsMelanocortin receptors ligandsImmunosuppressive agentsIinhibitors of hepatitis C virusHistamine H4 receptor agonistsNR2B/NMDA receptor antagonistsCB1 Antagonist for the treatment of obesityAntibacterial agentsInhibitor of TGF- receptor binding

Application

Indole-3-propionic acid (CAS 830-96-6) drives the synthesis of fluorescent strigolactone analogues and anti-tumor agents through strategic functionalization. It enables targeted receptor modulation. Researchers exploit its scaffold to develop melanocortin ligands, H4 agonists, and CB1 antagonists for metabolic disorders. This compound also inhibits TGF-β binding and hepatitis C virus replication. Its versatility shines in catalytic transformations—like NBS-acetic acid oxidation followed by Pd/H₂ reduction—to access oxindole derivatives with enhanced bioactivity.

Synthesis

  • Route1
    • null|null
      160320-11-6
    • ~78%
    • In-stock
      3-Indolepropionic acid|CS-W015945
      830-96-6

    References

    • Ruiz, Miriam; Sanchez, J. Domingo; Lopez-Alvarado, Pilar; Menendez, J. Carlos Tetrahedron, 2012 , vol. 68, # 2 p. 705 - 710
  • Route2
    • Indole, ≥99%|CS-1268948
      120-72-9
    • null|null
      79-10-7
    • ~48%
    • In-stock
      3-Indolepropionic acid|CS-W015945
      830-96-6

    References

    • Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
  • Route3
    • null|null
      10184-98-2
    • ~%
    • In-stock
      3-Indolepropionic acid|CS-W015945
      830-96-6

    References

    • Journal of the American Chemical Society, , vol. 67, p. 822

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.1851
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   3

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