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Structure of 830346-48-0
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5-Bromo-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione features a sterically hindered trifluoromethyl group and an electron-deficient fluorinated aryl moiety, enabling robust coupling in late-stage functionalization. The tetrahydropyrimidine core provides high stability under standard conditions, while the bromo substituent facilitates selective cross-coupling reactions. This scaffold delivers enhanced metabolic resistance and improved membrane permeability in bioactive molecule design.
5-Bromo-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its bromo and carbonyl functionalities offer orthogonal reactivity, while the trifluoromethyl and fluoro substituents enhance metabolic stability and modulate electronic properties. The compound exhibits good bench stability and facilitates efficient purification, supporting scalable synthesis of targeted heterocyclic candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: