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Structure of 832735-61-2
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5-Bromo-1-(difluoromethyl)pyridin-2(1H)-one features a bromine substituent at the 5-position and a difluoromethyl group at the 1-position of a pyridin-2-one core. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds through cross-coupling reactions. The combination of halogen and fluorinated side chain enhances metabolic stability and modulates lipophilicity for optimized pharmacokinetic profiles.
5-Bromo-1-(difluoromethyl)pyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromine handle and electron-deficient pyridinone core. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the lactam functionality offers hydrogen-bonding capacity and structural rigidity. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: